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In patients complaining of severe asthenia, with a non progressive neuro-oncological disease, and without criteria of depression revealed by HAD Hospital Anxiety and Depression scale, evaluation of fatigue will be done with the MFI 20 scale.

This phase 2 study is a prospective cohort study.

Concomitant serious illness unbalanced that may interfere with follow-up• A better radiological analysis of these heterogeneous tumors improves their classification and helps to better distinguish prognosis subgroups.

THe duration of the study is 4 years.

FDA-regulated Drug Product: No Studies a U.

Tolerance to Temozolomide defined by the frequencies and grades of adverse events defined by the CTCAE v5.

Then, the patients will be followed-up until progression, with clinical evaluations and MRI performed every 2-3 months.

Hereditary hypersensitivity to saccharose, glucose-galactose malabsorption syndrome or saccharase-isomaltase deficiency• 15-month life quality as measured by total score of European Organization for the Research and Treatment of Cancer Quality of Life questionnaires EORTC QLQ-C30 and EORTC QLQ-BN20 together [ Time Frame: At 15 months ]• The duration of treatment will be 12 months.

formal contraindication to surgery determined via discussion of the case with expert neurosurgeons during a national webmeeting GLITRAD• At the time of recurrence, treatment with focal radiation therapy will be administered 54 Gy in classical fractions.